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Polyethylene glycol modification of drugs, ie PEGylation
,
It is a protein engineering molecular modification method to chemically couple activated polyethylene glycol to proteins, peptides, small molecule organic drugs and liposomes. The polyethylene glycol modification of the drug can be divided into two stages.
The first stage of modification technology is limited to the application of low molecular weight monomethoxy polyethylene glycol
(<20000)
. Commonly used modifiers are monomethoxy polyethylene glycol succinate succinimide ester
(mPEG-SS)
Monomethoxypolyethylene glycol succinimide ester
(mPEG-SC)
Wait
,
Coupling polyethylene glycol with drug molecules via an ester bond or a triazine ring
,
This non-specific, unstable linkage allows a drug molecule to be linked to several polyethylene glycol molecules. However, the first generation of polyethylene glycol modified drugs usually showed instability, greater toxicity and immunogenicity.
,
There is no essential change in the nature of biological activity, pharmacokinetics and prototype drugs.
High relative molecular mass
(>20000)
The second stage modification technology characterized by polyethylene glycol modifier has the characteristics of linkage stability, fixed-point modification and controlled release.
,
The modified drug has higher biological activity, better physical and thermal stability, higher product uniformity and purity.
But always have to say
,
Protein drug
PEG
The biggest problem in the finishing technique is that fixed point decoration cannot be achieved.
,
Modified product is not uniform
,
It is very difficult to separate and purify
,
It also largely hinders clinical application. According to the amino acid nature of the protein and
PEG
Derivative characteristics
,
Researchers have developed a variety of strategies and methods for site-specific modification.
Some protein
N
End plays an important role in its biological activity
,
If at
N
Implementation
PEG
Modification will result in loss of biological activity of the protein
,
So will
PEG
Modified site transferred to
C
The end is an effective modification strategy. General choice
mPEG-
Acylhydrazine or
mPEG-
Amines modify proteins
,
The modification sites of the carboxyl group include aspartic acid, glutamic acid and terminal carboxyl groups.
mPEG-
A hydrazide is another modification agent developed in recent years that specifically binds to a carboxyl group.
Compared with lysine
,
Cysteine ​​has a low probability and a small number in proteins
,
Thiol-based reactivity
PEG
Derivatives can achieve protein site modification
,
But the disadvantage is that the thiol group of cysteine ​​is usually at the active center of the protein.
,
Modification will result in a large loss of protein activity. For proteins without cysteine, the thiol reaction site can be introduced by genetic engineering. This method not only enables highly selective modification
,
And can reduce the loss of protein biological activity
,
And reduce immunogenicity.
Currently available for thiol modification
mPEGs
include
mPEG-
Maleimide,
mPEG-
O-pyridine
-
Disulfide,
mPEG-
Vinyl sulfone and
mPEG-
Iodoacetamide and the like. among them
mPEG-
Simple preparation of maleimide
,
More applications.
PEG-
O-pyridine
-
a disulfide coupled with a protein
S-S
key
,
Slow hydrolysis under physiological conditions
,
Release natural protein
,
Conducive to the recovery of activity
,
However, the modification rate is low.
PEG-
Vinyl sulfone
pH7-9
Selective reaction with sulfhydryl groups
,
when
pH
When it is higher, it crosslinks with the amino group.
PEG-
The advantage of iodoacetamide is that after hydrolysis by strong acid
,
Release of cysteine ​​derivatives
,
Easy to identify.
Performing the disulfide bond contained in the protein
PEG
Fixed point modification
2
Steps
:
First, the use of a mild reducing agent to reduce the disulfide bond to release two sulfhydryl groups
;
The second step is passed
PEG
Dialkylation of modifiers to reconstitute disulfide bonds
,
Thereby completing
PEG
Fixed point decoration. There is no irreversible protein in the process of modifying the protein.
,
Moreover, the protein maintains its tertiary structure after disulfide bond reduction.
, PEG
Selective modification of two sulfur groups
, PEG
Stereo barrier function ensures
1
Only two disulfide bonds
1
molecular
PEG
. Disulfide bond
PEG
Modifications may be due to
PEG
Shielding effect
,
Reduce the biological activity of the protein.
Veronese
Using a denaturant
(3mol/L)
Denature the protein
,
Advanced structure opens
,
But do not use a reducing agent to protect the disulfide bond
,
Completed in an unfolded state
PEG
Modified
,
Removal of denaturant by dialysis or gel filtration chromatography
,
Re-folding the protein correctly to restore biological activity usually only the side chain group with polar amino acid residues can be carried out
PEG
Chemical modification.
Deiters
Etc. A method for the fixed-point modification of the non-polar amino acid phenylalanine
,
First, the phenylalanine in the protein is modified by a nucleophilic substitution reaction with an azide to form a para-azo alanine
,
Alkyne derived
PEG-
Amide modifier modified phenylalanine
,
Cyclic addition reaction occurs to form a stable linker
,
Thereby completing the site-specific modification of the protein. In addition
,
Introduction of azide-containing amino acid residues into proteins by genetic recombination
,
Re-specific
PEG
The modifier is coupled to form a stable site-directed single modification product.
Cazalis
Thrombomodulin
(Thrombomodulin)
of
C
Azide methionine
,
versus
mPEG2
Triarylphosphine
(mPEG2triarylphosphine)
The modifier produces a stable single modification
,
Although the method is more complicated
,
But at least give us a new one
PEG
The idea of ​​modifying the protein
This class
PEG
The principle of fixed point modification is
:
First, oxidizing a sugar residue with glucose oxidase or sodium sulfonate to produce a reactive aldehyde group
,
These aldehyde groups can be combined with
mPEG2
The hydrazine derivative reacts to form hydrazine or
mPEG2
Amine derivative reaction produces reversible
Schiff
Alkali. Reduction of hydrazine to a more stable alkyl halide with sodium borohydride
,
and
Schiff
The base can be reduced to a secondary amine. Relative to
mPEG-
Amine derivative modification
, PEG-
The hydrazine derivative modification does not form a crosslinked polymer
,
More suitable for sugar-based modification
,
Most representative
mPEG2
Anthracene derivative
mPEG2
Acylhydrazine
(hydrazide2mPEG)
. Very low hydrazide group
pKa
Value makes the hydrazide group in an acidic environment
(pH4.5
~
5.0)
Can still be combined with carboxyl groups
,
The amino group in the protein cannot react with the carboxyl group due to protonation under these conditions.
,
Thereby selective positioning modification can be achieved.
Due to the variety of proteins and complex structures
,
Often make
PEG
Modification reaction is not specific
,
The reaction conditions are optimized by a large number of tests. If computer technology can be used to theoretically calculate and analyze the surface properties of protein crystal structures
,
Identify possible reaction sites and groups
,
And design the appropriate linker according to the structural characteristics of the modified group and the modifier.
,
This will not only reduce
PEG
Modification blindness
,
And can improve research efficiency. Hu Yuandong, etc.
Insight
II
Molecular simulation software package
(BiosymInc., SanDiego, CA)
Bovine hemoglobin crystal
(bHb)
Structural analysis and molecular simulation
,
Calculated protein surface
twenty four
Can be carried out
PEG
decorative
Lys
Solvent accessible surface area of ​​residues and their major atoms
,
Determined which modifications can be made
13
One
Lys
Residues
(
Solvent accessible surface area
>0.4nm2),
And further designed a small molecule compound with bifunctional groups to activate oxirane
PEG
As a connector. The results show
, PEG
decorative
bHb
The biological indicators such as oxygen carrying capacity and immunogenicity all achieved the expected results.
PEG
Introduction of derivative reagent materials:
Shanghai Yanyi Biotechnology Co., Ltd. provides polyethylene glycol derivatization reagents.
PEG
The groups that can be modified include the following:
PEG-OH
Hydroxyl
PEG-NHS
Activated fat
PEG-SG
Succinimide glutarate
Succinimidyl Glutarate
PEG-MAL
Maleimide
PEG-SH
Base
PEG-Silane
Silane
PEG-NH2
Amino
PEG-Biotin
Biotin
PEG-SS
Succinimide succinate
Succinimidyl Succinate
PEG-GAS
PEG-ALD
Propionaldehyde
PEG-NPC
P-nitrophenyl carbonate
PEG-OPSS
O-dithiopyridine
PEG-Hydrazide
Acid well
PEG-Acrylate
Methoxy
-
Polyethylene glycol
-
Acrylate
PEG-Azide
Azide
PEG-Alkyne
Alkynyl
PEG-CHO
Aldehyde
PEG-DSPE
Distearate phosphatidylethanolamine
PEG-FITC
Fluorescein isothiocyanate
PEG-RB
Luo Danming
B
PEG-Chloride
chloride
PEG-COOH
carboxyl
PEG-EPO
PEG-SVA
Succinimide valerate
PEG-SPA
Succinimide propionate
PEG-DBCO
PEG-LA
Lipoic acid
PEG-
cholesterol
PEG-Folic Acid
Folic acid
mPEG L-Lysine
Lysine
mPEG Cysteine
Cysteine
mPEG Glutathione
Glutathione
mPEG Aspartic Acid
Aspartic acid
mPEG Glutamic Acid
Polylysine PEG
Dextran PEG
BSA PEG Conjugate
Detailed product list introduction of polyethylene glycol modified products
:
Amino product catalogue:
mPEG-NHS, MW: 2000
mPEG-CHO, MW: 350
mPEG-NPC, MW: 550
mPEG-PFP, MW: 1000
mPEG-SS-NHS, MW: 3400
mPEG-SPA, MW: 5000
mPEG-SVA, MW: 750
NHS-PEG-NHS, MW: 10000
NHS-PEG-MAL, MW: 5000
NHS-PEG-Biotin, MW: 2000
NHS-PEG-FITC, MW: 5000
NHS-PEG-Silane, MW: 20000
Diethoxylsilane-PEG-NHS, MW: 5000
Monoethoxylsilane-PEG-NHS, MW: 5000
NHS-PEG-DSPE, MW: 2000
NHS-PEG-CLS, MW: 1000
NHS-PEG-COOH, MW: 3400
NHS-PEG-OH
CHO-PEG-CHO, MW: 550
NPC-PEG-NPC, MW: 1000
mPEG-EPO, MW: 20000
EPO-PEG-EPO, MW: 1000
mPEG-ISC, MW:40000
mPEG-ITC. MW: 2000
ISC-PEG-ISC, MW: 3400
mPEG-Tosylate, MW: 5000
å·¯ based product catalogue:
Maleimide PEG, mPEG-MAL, MW: 2000
Maleimide PEG Maleimide, MAL-PEG-MAL, MW: 1000
Maleimide PEG NHS, MAL-PEG-NHS, MW: 750
Maleimide PEG PFP, MAL-PEG-PFP, MW: 3400
Maleimide PEG Biotin, MAL-PEG-Biotin, MW: 5000
Maleimide PEG Fluorescein, MAL-PEG-FITC, MW: 1000
Maleimide PEG Silane, MAL-PEG-Silane, MW: 3400
Maleimide PEG Amine, MAL-PEG-NH2, MW: 2000
Maleimide PEG Acid, MAL-PEG-COOH, MW: 10000
Ortho-pyridine disulfide PEG, mPEG-OPSS, MW: 750
OPSS-PEG-OPSS, MW: 1000
OPSS-PEG-NHS, MW: 2000
OPSS-PEG-Biotin, MW: 2000
OPSS-PEG-NH2, MW: 3400
OPSS-PEG-COOH, MW: 550
Iodoacetyl PEG, mPEG-IA, MW: 20000
Iodoacetyl PEG NHS, IA-PEG-NHS, MW: 5000
Iodoacetyl PEG Maleimide, IA-PEG-MAL, MW: 2000
Iodoacetyl PEG amine, IA-PEG-NH2, MW: 3400
Iodoacetyl PEG Biotin, IA-PEG-Biotin, MW: 1000
Iodoacetyl PEG Acid, IA-PEG-COOH, MW: 5000
PEG di-iodoacetate, IA-PEG-IA, MW: 3400
Vinylsulfone PEG, mPEG-VS, MW: 2000
Vinylsulfone PEG acid, VS-PEG-COOH, MW: 1000
Vinylsulfone PEG Fluorescein, VS-PEG-FITC, MW: 5000
Vinylsulfone PEG Biotin, VS-PEG-Biotin, MW: 20000
Vinylsulfone PEG DSPE, VS-PEG-DSPE, MW: 550
Vinylsulfone PEG Silane, VS-PEG-Silane, MW: 3400
Monofunctional PEGs
Product catalogue:
Methoxyl PEG, mPEG-OH
Amino PEG, Methoxy PEG Amine, mPEG-NH2
Carboxylic PEG acid, mPEG-COOH
Thiol PEG, methoxy PEG Thiol, mPEG-SH
Azido PEG, mPEG-N3
Hydrazide PEG, mPEG-HAZ
Acrylate PEG, mPEG-ACR
Succinimidyl PEG NHS, mPEG-NHS(SC)
Succinimidyl propionic acid PEG NHS, mPEG-SPA
Succinimidyl valeric acid PEG NHS, mPEG-SVA
Methoxyl PEG Aldehyde, mPEG-CH2CHO
PEG Nitrophenyl Carbonate PEG, mPEG-NPC
Epoxide PEG, mPEG-EPO
Isocyanate PEG, mPEG-ISC
Isothiocyanate PEG, mPEG-ITC
Maleimide PEG, mPEG-MAL
Ortho-pyridine disulfide PEG, mPEG-OPSS
Iodoacetyl PEG, mPEG-IA
Vinylsulfone PEG, mPEG-VS
PEG Biotin, mPEG-Biotin
Fluorescein PEG, mPEG-FITC
Rhodamine-PEG, mPEG-RB
Silane PEG, mPEG-Silane
Lipoic acid PEG, mPEG-LA
DSPE PEG, mPEG-DSPE
DMPE PEG, mPEG-DMPE
DPPE PEG, mPEG-DPPE
DLPE PEG, mPEG-DLPE
Cholesterol PEG, mPEG-CLS
DBCO PEG, mPEG-DBCO
Homobifunctional PEG
product list:
HO-PEG-OH
Amino PEG Amine, NH2-PEG-NH2
Thiol PEG Thiol, HS-PEG-HS
Carboxylic Acid PEG Acid, HOOC-PEG-COOH
Hydrazide-PEG-Hydrazide
Aldehyde PEG Aldehyde, CHO-PEG-CHO
Bifunctional NHS PEG, NHS-PEG-NHS
Bifunctional NPC PEG, NPC-PEG-NPC
Epoxide PEG Epoxide, EPO-PEG-EPO
Isocyanate PEG Isocyanate, ISC-PEG-ISC
Maleimide PEG Maleimide, MAL-PEG-MAL
OPSS-PEG-OPSS
PEG di-iodoacetate, IA-PEG-IA
Biotin-PEG-Biotin
PEG di-vinylsulfone, VS-PEG-VS
PEG di-acrylate, Acrylate-PEG-Acrylate
CDI-PEG-CDI
PFP-PEG-PFP, pentafluorophenyl PEG
Heterobifunctional PEG
product list:
Amino PEG Acid, NH2-PEG-COOH
Amino PEG hydroxyl, NH2-PEG-OH
Maleimide PEG NHS, MAL-PEG-NHS
Maleimide PEG PFP, MAL-PEG-PFP
Maleimide PEG Amine, MAL-PEG-NH2
Maleimide PEG Acid, MAL-PEG-COOH
NHS-PEG-COOH
NHS-PEG-OH
Biotin-PEG-NHS
Biotin-PEG-NH2
Biotin-PEG-COOH
Biotin-PEG-Maleimide
Biotin-PEG-FITC
Biotin PEG Thiol, Biotin-PEG-SH
Thiol PEG Amine, HS-PEG-NH2
Thiol PEG Acid, HS-PEG-COOH
Thiol PEG OH, HS-PEG-OH
Thiol PEG Azide, HS-PEG-N3
Thiol PEG Fluorescein, HS-PEG-FITC
DSPE-PEG-NHS
DSPE-PEG-Maleimide, DSPE-PEG-MAL
DSPE PEG Biotin
DSPE PEG Amine, DSPE-PEG-NH2
DSPE PEG Acid, DSPE-PEG-COOH
Silane-PEG-Amine
Silane-PEG-COOH
Silane-PEG-Biotin
Silane-PEG-Maleimide
Silane-PEG-NHS
Silane-PEG-SH
Azido PEG hydroxyl, N3-PEG-OH
Azido PEG amine, N3-PEG-NH2
Azido PEG acid, N3-PEG-COOH
Azido PEG NHS, N3-PEG-NHS
Azido PEG Maleimide, N3-PEG-Mal
Azido PEG Biotin, N3-PEG-Biotin
Fluorescein PEG NHS, FITC-PEG-NHS
Fluorescein PEG Amine, FITC-PEG-NH2
Fluorescein PEG Maleimide, FITC-PEG-Mal
Fmoc-NH-PEG-NHS
Fmoc-NH-PEG-NH2
Fmoc-NH-PEG-COOH
Boc-NH-PEG-NHS
Boc-NH-PEG-NH2
Boc-NH-PEG-COOH
Acryloyl PEG COOH
Acryloyl PEG NHS
Acryloyl PEG NH2
Alkyne PEG amine, Alkyne-PEG-NH2
Alkyne PEG acid, Alkyne-PEG-COOH
Alkyne PEG thiol, Alkyne-PEG-SH
Alkyne PEG NHS, Alkyne-PEG-NHS
Alkyne PEG Maleimide, Alkyne-PEG-Mal
Alkyne PEG Biotin, Alkyne-PEG-Biotin
Biotinylated PEGs
Product List:
PEG Biotin, mPEG-Biotin
Biotin-PEG-NHS
Biotin-PEG-PFP
Biotin-PEG-NH2
Biotin PEG hydrazide
Biotin-PEG-COOH
Biotin-PEG-OH
Biotin-PEG-Maleimide
Biotin-PEG-FITC
Biotin-PEG-Biotin
Biotin-PEG-SH
Other Fluorescent PEG Biotin
Folic Acid PEG Biotin
Desthiobiotin-PEG-X
Iminobiotin-PEG-X
Product List
Surface Reactive PEGs
:
Silane PEG, mPEG-Silane
Silane-PEG-Amine
Silane-PEG-COOH
Silane-PEG-Biotin
Silane-PEG-Maleimide
Silane-PEG-NHS
Silane-PEG-SH
Silane-PEG-OPSS
Silane-PEG-FITC
Silane-PEG-Acrylate
Silane-PEG-N3, Silane PEG Azide
Thiol PEG, methoxy PEG Thiol, mPEG-SH
Thiol PEG Amine, HS-PEG-NH2
Thiol PEG Acid, HS-PEG-COOH
Thiol PEG NHS, HS-PEG-NHS
Thiol PEG OH, HS-PEG-OH
Thiol PEG Biotin, HS-PEG-Biotin
Thiol PEG Azide, HS-PEG-N3
Thiol PEG Alkyne, HS-PEG-Alk
Thiol PEG Fluorescein, HS-PEG-FITC
Lipoic acid PEG, mPEG-LA
Lipoic acid PEG amine, LA-PEG-NH2
Lipoic acid PEG acid, LA-PEG-COOH
Lipoic acid PEG NHS, LA-PEG-NHS
Lipoic acid PEG, LA-PEG-Biotin
Lipoic acid PEG, LA-PEG-OH
Lipoic acid PEG, LA-PEG-FITC
Lipoic acid PEG, LA-PEG-NHS
Lipoic acid PEG, LA-PEG-MAL
Fluorescent PEGs
Product catalogue:
Fluorescein PEG, mPEG-FITC
Fluorescein PEG Amine, FITC-PEG-NH2
Fluorescein PEG hydroxyl, FITC-PEG-OH
Fluorescein PEG acid, FITC-PEG-COOH
Fluorescein PEG Thiol, FITC-PEG-SH
Fluorescein PEG Biotin, FITC-PEG-Biotin
Fluorescein PEG NHS, FITC-PEG-NHS
Fluorescein PEG Azide, FITC-PEG-N3
Fluorescein PEG Maleimide, FITC-PEG-Mal
Rhodamine-PEG, mPEG-RB
Rhodamine PEG hydroxyl, RB-PEG-OH
Rhodamine PEG Amine, RB-PEG-NH2
Rhodamine PEG Thiol, RB-PEG-SH
Rhodamine PEG Acid, RB-PEG-COOH
Rhodamine PEG Biotin, RB-PEG-Biotin
Rhodamine-PEG-NHS, RB-PEG-NHS
Rhodamine-PEG-MAL, RB-PEG-MAL
Cy5 PEG Amine, Cy5-PEG-NH2
Cy5 PEG NHS, Cy5-PEG-NHS
Cy5 PEG acid, Cy5-PEG-COOH
Cy5 PEG Maleimide, Cy5-PEG-Mal
Cy5 PEG Thiol, Cy5-PEG-SH
Cy5 PEG Biotin, CY5-PEG-Biotin
Cy5 PEG Folic acid, Cy5-PEG-FA
Cy3 PEG Amine, Cy3-PEG-NH2
Cy3 PEG NHS, Cy3-PEG-NHS
Cy3 PEG acid, Cy3-PEG-COOH
Cy3 PEG Maleimide, Cy3-PEG-Mal
Cy3 PEG Thiol, Cy3-PEG-SH
Cy3 PEG Biotin, Cy3-PEG-Biotin
Cy3 PEG Folic acid, Cy3-PEG-fa
Other Cy3 PEG Derivatives
Click PEG Derivatives
Product catalogue:
mPEG-DBCO
DBCO PEG NHS, DBCO-PEG-NHS
DBCO PEG Maleimide, DBCO-PEG-MAL
DBCO PEG Amine, DBCO-PEG-NH2
DBCO PEG acid, DBCO-PEG-COOH
DBCO PEG DSPE
DBCO PEG Silane
DBCO PEG Biotin
DBCO PEG Flurorescein, DBCO-EPG-FITC
DBCO PEG Cy3
DBCO PEG Cy5
Polymerizable PEGs
Product catalogue:
Acrylate PEG, mPEG-ACR
Methacrylate PEG, mPEG-MACR
Acrylate PEG NHS
Acrylate PEG Maleimide
Acrylate PEG Biotin
Acrylate PEG Amine, Acrylate-PEG-NH2
Acrylate PEG Acid, Acrylate-PEG-COOH
Acrylate PEG Acrylate
Multiarm PEGs
Product catalogue:
2 Arm/Branched PEG Acid 10000 Da
2 Arm/Branched PEG Acid 4000 Da
2 Arm/Branched PEG Amine 10000 Da
2 Arm/Branched PEG Amine 4000 Da
2 Arm/Branched PEG NHS 10000 Da
2 Arm/Branched PEG NHS 4000 Da
2 Arm/Branched PEG Maleimide 10000 Da
2 Arm/Branched PEG Maleimide 4000 Da
2 Arm/Branched PEG Biotin 10000 Da
2 Arm/Branched PEG Biotin
4-Arm PEG Acrylate
4-Arm PEG Amine
4-Arm PEG Thiol
4-Arm PEG Maleimide
4-Arm PEG NHS
4-Arm PEG Biotin
4 Arm PEG vinyl sulfone
8-Arm PEG Amine
8-Arm PEG Thiol
8-Arm PEG NHS
8-Arm PEG Maleimide
8-Arm PEG Biotin
8 Arm PEG vinyl sulfone
Other PEG Reagents
Product catalogue:
Folic Acid PEG, mPEG-FA Folic
Acid PEG Amine, FA-PEG-NH2
Folic Acid PEG Acid, FA-PEG-COOH
Folic Acid PEG Thiol, FA-PEG-SH
Folic Acid PEG DSPE
Folic Acid PEG NHS
Folic Acid PEG Maleimide
Folic Acid PEG Biotin
Folic Acid PEG FITC
Vitamin E PEG, mPEG alfa-tocopherol
Vitamin E PEG, mPEG alfa-tocopherol
Vitamin E PEG, mPEG alfa-tocopherol
Vitamin E PEG NHS, Tocopherol PEG NHS
Vitamin E PEG NHS, Tocopherol PEG NHS
Vitamin E PEG NHS, Tocopherol PEG NHS
Vitamin E PEG NH2, Tocopherol PEG amine
Vitamin E PEG NH2, Tocopherol PEG amine
Vitamin E PEG NH2, Tocopherol PEG amine
Vitamin E PEG Maleimide, Tocopherol PEG maleimide
Vitamin E PEG Maleimide, Tocopherol PEG maleimide
Vitamin E PEG Maleimide, Tocopherol PEG maleimide
Vitamin D PEG, mPEG Vitamin D
Vitamin D PEG, mPEG Vitamin D
Vitamin D PEG, mPEG Vitamin D
Vitamin D PEG, mPEG Vitamin D
Vitamin D PEG, mPEG Vitamin D
Vitamin D PEG NHS
Vitamin D PEG NHS
Vitamin D PEG NHS
Vitamin D PEG NH2
Vitamin D PEG NH2
Vitamin D PEG NH2
Vitamin D PEG Maleimide
Vitamin D PEG Maleimide
Vitamin D PEG Maleimide
Vitamin A/Retinoic acid PEG, mPEG Retinoic acid
Vitamin A/Retinoic acid PEG, mPEG Retinoic acid
Vitamin A/Retinoic acid PEG, mPEG Retinoic acid
Retinoic acid PEG NHS
Retinoic acid PEG Biotin
Retinoic acid PEG FITC
PEG amino acid/peptide Conjugates
Product List:
mPEG L-Lysine
mPEG L-Lysine
Lysine PEG Lysine
4 Arm PEG L-Lysine
8 Arm PEG L-Lysine
mPEG Cysteine
Cysteine ​​PEG Cysteine
4 Arm PEG Cysteine
mPEG Glutathione
Glutathione PEG Glutathione
4 Arm PEG Glutathione
mPEG Aspartic Acid
Aspartic Acid PEG Aspartic Acid
4 Arm PEG Aspartic Acid
mPEG Glutamic Acid
Glutamic Acid PEG Glutamic Acid
4 Arm PEG Glutamic Acid
PEG Metal Chelate Conjugates
mPEG DTPA
DTPA PEG Biotin
DTPA PEG FITC
4A PEG DTPA
mPEG NTA
NTA PEG Biotin
NTA PEG FITC
4A PEG NTA
NTA PEG Biotin
NTA PEG Biotin
BSA PEG Conjugate
Polylysine PEG Conjugate
Polylysine PEG Conjugate
Dextran PEG Conjugate
Dextran PEG Conjugate
Chymotrypsin PEG Conjugate
Superoxide Dimutase PEG
Lipase PEG
PEG esterase
Shanghai Yanyi Biotechnology Co., Ltd.'s main business
--PEG
Modification reagent, company since
2008
Custom synthesis
PEG
Modifier. Sales at the same time
PEG
, acting in the United States
Creative
And the United States
Laysan
Such brands have been sold in China.
PEG
The most complete range of products, also domestic sales
PEG
One of the most influential companies.
Shanghai Yanyi Bio-launched domestically produced
PEG
Brand
YareBio
The advantages are as follows:
Domestic
PEG
The most complete range (up to three thousand
PEG
Modified product)
Product quality is stable and reliable (purity is greater than
95%
)
Low sales price (most product prices are foreign
50%
Even lower)
After-sales service is guaranteed (if there are any quality problems, you can return)
Can provide a variety of complexities
PEG
Synthetic customization service
Fstn Display,Fstn Screen,Positive Lcd Display,Fstn Lcd Display
Huangshan Kaichi Technology Co.,Ltd , https://www.kaichitech.com